Why Autoimmune Syndrome Patients are affected by Recurrent Yeast Infections
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Researchers from Rockefeller University have reported in the Journal of Experimental Medicine that sufferers of a rare autoimmune disorder are more likely to get yeast infection because of an antibody they are making that kills the proteins that would fight the yeast and keep it under control.
The Autoimmune syndrome is called APS-1 or autoimmune polyendocrine syndrome and researchers looked at 33 patients. In these patients the researchers found the immune proteins called cytokines were being attacked by antibodies. There are several types of cytokines but the ones in the blood in this study were those that are known to help humans’ immune systems by protecting against bacterial infections.
Head of the Laboratory of Human Genetics of Infectious Diseases at Rockefeller University and leading the research is Jean-Laurent Casanova. He says,
“These cytokines, particularly the family comprising interleukin 17A, 17F and 22, have recently been implicated in defending against yeast overgrowth, but this is the first time it has been shown in humans. The next step is to find genetic mutations in these cytokines in patients with Candidiasis, as only this will prove the causal relationship.”
There are already drugs available to treat APS-1 patients that are designed to lower B cells that make the antibodies that attack the cytokine, thus taking then out.
http://www.sciencedaily.com/releases/2010/04/100410140439.htm
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