A New Strategy To Treat the Common Yeast Infection
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A group of researchers from GUMC (Georgetown University Medical Center) have found a way to improve treatment of yeast infections caused by the fungus Candida Albicans such as Thrush, diaper rash, vaginal infections, as well as the more life threatening forms such as systemic that invade the blood stream and can be life threatening. This fungus lives on most humans and the researchers’ findings involve inhibiting a key protein so that a new drug can more effectively target the yeast.
A quote from the study’s lead author Richard Calderone, PhD, professor and chair of the department of microbiology and immunology and co-director of the PhD program in the global infectious disease program at GUMC says,
“This is a genetically intelligent approach to target identification and drug design. Candida infections are often treatable, however, in patients that are immunocompromised following cancer chemotherapy, bone marrow transplantation, or surgery, diagnosis is often delayed, postponing therapy,”
he adds,
“Also when drug-resistant yeast pathogens cause the infection, clinical management of the patient becomes a problem.”
At the moment, the health care pays around 1.8 billion dollars a year duet to the fourth most common infection acquired in hospital, invasive and blood borne Candida infections.
Calderone observes that
“More drug resistance is being seen clinically, so there is significant room for improvement in the therapies used today,”
The team are looking at a new drug that will have improved targeting of the fungus where no toxicity is produced. There is a gene identified as Ssk1 that if removed from the Candida Albicans makes the triazole drugs more effective in the laboratory. The hope is this will lead to more effective treatment options outside the lab. The researchers found that the Ssk1 gene was essential to the fungus and so an inhibitor may help a treatment or be the treatment itself.
And if it works on Candida it may have broader implications as Ssk1p is found in other fungi. The team are now working with other researchers to find the right agent that will target the protein.
Source: MedicalNewsToday.Com
http://www.medicalnewstoday.com/articles/127147.php
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